Lunds universitet, Naturvetenskapliga fakulteten, kemiska institutionen

Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has 42 000 students and 7 400 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

The Faculty of Science conducts research and education within Biology, Astronomy, Physics, Geosciences, Chemistry, Mathematics and Environmental Sciences. The Faculty is organized into ten departments, gathered in the northern campus area. The Faculty has approximately 1900 students, 330 PhD students and 700 employees.

Job assignment

Peptide-lipid co-assembly is an important phenomenon of high relevance for peptide biomaterials as well as diseases such as Parkinson's and Alzheimer's. However, this co-assembly is not well understood. The overall aim of this project is to better understand the underlying molecular mechanisms behind this and its structural and functional consequences. You will develop and use a combination of new biophysical techniques to study the co-assembly on a single molecule level.

The job assignments will be mainly experimental and you will be part of a collaborative network of students and researchers at the divisions of Physical Chemistry (http://www.fkem1.lu.se) as well as Biochemistry and Structural Biology (http://www.cmps.lu.se/biostruct/) at Lund University. We recently found that it is possible to trap and manipulate molecules on cell membrane mimics using hydrodynamic forces from a micropipette. You will utilize and further develop this technique to study how individual peptide-lipid aggregates form. You will also have access to state-of-the-art single molecule fluorescence microscopes and be part of setting up a superresolution fluorescence microscope to obtain high resolution data on the molecular mechanisms of the co-assembly and its properties. This will provide novel information on how these important molecules interact under different conditions and can also contribute to a better understanding of how these molecules cause damage in neurodegenerative diseases.

The main supervisor for the project is Associate Senior University Lecturer Peter Jönsson at the Division of Physical Chemistry with a research focus in biomolecular interactions at interphases. The PhD student will be positioned at the Division of Physical Chemistry, but will also be closely collaborating with postdocs and students in the groups of Profs. Ulf Olsson, Sara Snogerup Linse, Emma Sparr and Daniel Topgaard that are all involved in the research program.

Qualifications

The applicant should have a MSc or MEng in physics or chemistry, or a similar degree on advanced level. Since the PhD studies will include both method optimization as well as application of different techniques to study biophysical problems it is essential that the applicant has an interest in both these areas. Documented experience in setting up and working with fluorescence microscopy, and especially single molecule and/or superresolution microscopy, is a merit. It is also important that the applicant has a documented ability to be able to readily acquire new techniques and knowledge. Furthermore, experience in working with lipid bilayers, peptide aggregation, image and data analysis and development of new biophysical techniques is also a merit. Other important personal qualities of the applicant are to be structured, independent, perseverant and energetic. A good understanding of both written and spoken English is a requisite. Excellent communication and presentation skills are also essential. The candidate should have the ability to work in a team and collaborate with people from complementary disciplines.

Please, attach documentation that confirm your claimed merits and a personal letter that explains your interest for the project and the knowledge and experience you have that is relevant for this.


Eligibility
Students with basic eligibility for third-cycle studies are those who- have completed a second-cycle degree- have completed courses of at least 240 credits, of which at least 60 credits are from second-cycle courses, or- have acquired largely equivalent knowledge in some other way, in Sweden or abroad.

The employment of doctoral students is regulated in the Swedish Code of Statues 1998: 80. Only those who are or have been admitted to PhD-studies may be appointed to doctoral studentships. When an appointment to a doctoral studentship is made, the ability of the student to benefit from PhD-studies shall primarily be taken into account. In addition to devoting themselves to their studies, those appointed to doctoral studentships may be required to work with educational tasks, research and administration, in accordance with specific regulations in the ordinance.

Type of employment
Limit of tenure, four years according to HF 5 kap 7§.

Type of employment Temporary position longer than 6 months
First day of employment Upon agreement
Salary Monthly salary
Number of positions 1
Working hours 100 %
City Lund
County Skåne län
Country Sweden
Reference number PA2017/1441
Contact
  • Peter Jönsson, Associate Senior Lecturer, +46 46 222 81 60; peter.jonsson@fkem1.lu.se
Union representative
  • OFR/ST:Fackförbundet ST:s kansli, 046-222 93 62, st@st.lu.se
  • SACO:Saco-s-rådet vid Lunds universitet, 046-222 93 64, kansli@saco-s.lu.se
Published 02.May.2017
Last application date 23.May.2017 11:59 PM CET

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